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Activated through the antibiotic rifampicin and several plant metabolites, for example hyperforin, guggulipid, colupulone, and isoflavones. Reaction to precise ligands is species-unique. Activated by Obviously taking place steroids, like pregnenolone and progesterone. Binds into a response aspect while in the promoters in the CYP3A4 and ABCB1/MDR1